Citation: C. Grehl (2021-02-18): Severe cases of COVID-19 are associated with changes in circulating small RNA abundance. DOI:10.5447/ipk/2021/17

Abstract: RNA-interference is described as an evolutionary conserved, host defense mechanism against viral infection. Up to now only minor effort was taken to investigate the relevance of this mechanism for clearance of the SARS-CoV-2 RNA virus in infected individuals. Small circulating RNAs were investigated from serum samples of COVID-19 patients. Small RNAs were analyzed by high throughput sequencing from five mild cases, five severe cases and two control samples. Here, we profile the plasma of patients with mild and severe COVID-19 for the presence of small circulating RNAs during active and convalescene using high throughput sequencing. As result the presence of SARS-CoV-2 derived small RNAs in serum samples of mild and severe COVID-19 cases is described.

License: CC BY 4.0 (Creative Commons Attribution)

DOI: 10.5447/ipk/2021/17

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Metadata
CONTRIBUTOR:
Markus Kuhlmann, Ivo Grosse, Thomas Altmann, Mascha Binder, Christoph Schultheiss, Katrin Hoffmann [Show full information]
CREATOR:
Claudius Grehl [Show full information]
PUBLISHER: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Seeland OT Gatersleben, Corrensstraße 3, 06466, Germany
SIZE: 19.6 GB
SUBJECT: COVID-19, RNAi, SARS-CoV2, circulating-miRNA, small RNA
COVERAGE: none
DATE: Event: event
CREATED: TimePoint: Thu Feb 18 11:01:34 CET 2021
UPDATED: TimePoint: Thu Feb 18 13:52:03 CET 2021
LANGUAGE: de_DE
RELATION: none
SOURCE: none
Revision: 2 - CreationDate: Thu Feb 18 11:01:34 CET 2021 - RevisionDate: Thu Feb 18 13:52:03 CET 2021